A study on the inhibitory mechanism for cholesterol absorption by α-cyclodextrin administration

• Takahiro Furune,
• Naoko Ikuta,
• Yoshiyuki Ishida,
• Hinako Okamoto,
• Daisuke Nakata,
• Keiji Terao and
• Norihiro Sakamoto

Beilstein J. Org. Chem. 2014, 10, 2827–2835, doi:10.3762/bjoc.10.300

• solubility of cholesterol in the lumen of the small intestine via the precipitation of lecithin from bile salt micelles by complex formation with α-CD. It further indicates that the lecithin precipitation effect on the bile salt micelles by α-CD addition clearly differs from addition of other water-soluble

• dietary fibers. The decrease in micellar cholesterol solubility in the FeSSIF was the strongest with α-CD addition. Keywords: α-cyclodextrin; bile salt micelles; cholesterol; lecithin; micellar solubility; Introduction α-Cyclodextrin (α-CD) is a ring molecule composed of six glucose units that has an

• ][25]. Conversely, it has been reported that α-CD releases lecithin from the cell membrane [26][27][28][29][30]. In this study, we investigated the effect of α-CD on the mixed micelles (bile salt micelles) using Fed-State Simulated Intestinal Fluid (FeSSIF) [31] and the effect of α-CD on the micellar